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Primary Hyperparathyroidism

Primary Hyperparathyroidism

Primary hyperparathyroidism is usually caused by a single, hyperfunctioning benign parathyroid tumor that secretes too much parathyroid hormone. The most common manifestation is high blood calcium levels, but symptoms such as kidney stones, osteoporosis, bone pain, fractures, reflux disease and others may be the presenting symptoms.

About 5 percent of patients have four-gland diffuse parathyroid hyperplasia, which is an enlargement and overproduction of parathyroid hormone in all four glands. In some patients with this form of primary hyperparathyroidism, the condition runs in the family either by itself or with other tumors as a part of multiple endocrine neoplasia syndromes (type 1, 2A or familial hyperparathyroidism).

What are the signs and symptoms of primary hyperparathyroidism?

Hyperparathyroidism can be asymptomatic and cause mild symptoms or, in rare cases, severe symptoms. They include:

• Anxiety
• Mood swings
• Depression
• Forgetfulness
• Irritability
• Concentration problems
• Fatigue
• Kidney/urinary issues
• Kidney stones
• Nocturia (excessive urination at night)
• Worsening kidney function
• Digestive issues
• Stomach or duodenal ulcer
• GERD (acid reflux)
• Pancreatitis
• Abdominal pain
• Constipation
• Musculoskeletal issues
• Bone pain
• Joint pain
• Bone fractures
• Osteoporosis
• Generalized weakness

Related to Primary Hyperparathyroidism

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